More About Filaggrin
Filaggrin the gene
Definition: Homo sapiens filaggrin (FLG), mRNA.
Accession Number: NM_002016
Location: chromosome 1q21.3
Length: 12747 bp
Accession Number: NM_002016
Location: chromosome 1q21.3
Length: 12747 bp
| Download to view the DNA sequence in FASTA format: filaggrin.txt |
EntrezGene summary for FLG:
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediatefilaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting ofmultiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequentlyproteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated withichthyosis vulgaris.
UniProtKB/Swiss-Prot: FILA_HUMAN, P20930
Function: Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediatefilaments during terminal differentiation of mammalian epidermis
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediatefilaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting ofmultiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequentlyproteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated withichthyosis vulgaris.
UniProtKB/Swiss-Prot: FILA_HUMAN, P20930
Function: Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediatefilaments during terminal differentiation of mammalian epidermis
Filaggrin the protein
Definition: filaggrin [Homo sapiens]
Accession Number: NP_002007
Type: linear
Location: chromosome 1q21.3
Length: 4061 aa
Accession Number: NP_002007
Type: linear
Location: chromosome 1q21.3
Length: 4061 aa
| Download to view the amino acid sequence in FASTA format: filaggrin.txt |
